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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Aliment Pharmacol Ther. 2018 Sep;48(6):682–683. doi: 10.1111/apt.14864

Figure 1.

Figure 1

Structures of vonoprazan fumarate and DWP14012 hydrochloride. The benefits of these two P-CABs are predicted to be: (1) Elevation of pH to >5.0, 24 hours from a single dose; (2) Improved treatment of acid-related diseases; (3) Eradication of H. pylori in combination with amoxicillin only; (4) Immediate onset of action; (5) No requirement for enteric coating; (6) Meal independence; (7) Easy solution formulation. A dose of 40 mg once a day would maintain a pH >5.0 for 24 hours per day.