Fig 1. In vitro model for severe placental hypoxia and testing the vascular effect of PSMs.

Schematic overview of the In vitro model for PE where placental explants are exposed to severe hypoxia and PSMs are tested on chorionic arteries. Differences in contractile response are used as read-out (A) and a schematic overview for measuring the acute (ΔI) and sustained (ΔII) vascular effect of PSMs (B).