Table 1:
The Orphan Receptor Subfamily.
| Unified Nomenclature | Common Abbreviations | Date Identified | Discovered By | Ligand |
|---|---|---|---|---|
| NR3B | Nreb1/ERRα | 1988 | [84] | |
| Nr3b2/Errβ | 1988 | [84] | ||
| Nr3b3/Errγ | 1998 | [109] | ||
| NR4A | Nr4a1/Nur77 (Ngfi-b, Tr3, N10, Nak-1, St-59), | 1988 | [110, 111] | |
| Nr4a2/Nurr1 (Rnr-1, Not, Tinur) | 1992 | [112] | ||
| Nr4a3/Nor1 (Tec, Minor, Chn) | 1995 | [113] | ||
| NR2F | Nr2f2/Coup-tfII | 1988 | [114] | |
| Nr2f6/Ear2 | 1988 | [114] | ||
| Nr2f1/Coup-tfI | 1989 | [115] | ||
| NR2C | Nr2c1/Tr2 | 1988 | [116] | |
| Nr2c2/Tr4 | 1994 | [117] | ||
| NR1D | Nr1d1/Rev-erbα | 1989 | [118] | Heme [119–122] |
| Nr1d2/Rev-erbβ | 1994 | [123] | ||
| NR2B | Nr2b1/Rxrα | 1990 | [90] | 9-CIS retinoic acid as well as interacting with other NR [89, 124–127] |
| Nr2b2/Rxrβ | 1991 | [128] | ||
| Nr2b3/Rxrγ | 1991 | [129] | ||
| NR2E | Nr2e1/T1x | 1990 | [130] | |
| Nr2e3/Pnr | 1999 | [131, 132] | ||
| NR1C | Nr1c1/Pparα | 1990 | [85] | Fatty acids [133, 134] |
| Nr1c2/Pparβ or δ | 1993 | [135] | ||
| Nr1c3/Pparγ | 1993 | [135] | ||
| NR5A | Nr5a/Sf1 | 1992 | [136] | Phospholipids [137] |
| Nr5a2/Lrh1 | 1992 | [138] | ||
| NR1F | Nr1f1/Rorα | 1993 | [139] | Sterols ? |
| Nr1f2/Rorβ | 1993 | [139] | ||
| Nr1f3/Rorγ | 1996 | [140]. | ||
| NR2A | Nr2a1/Hnfα | 1994 | [141] | Fatty acids ? [142] |
| Nr2a2/Hnfγ | 1996 | [143] | ||
| NR1I | Nr1i3/Car | 1994 | [144] | Xenobiotics and endobiotic [79] |
| Nr1i2/Pxr | 1998 | [145–148] | ||
| NR6A | Nr6a1/Gcnf | 1994 | [149] | |
| NR0B | Nr0b1/Dax-1 | 1994 | [150] | |
| Nr0b2/Shp | 1996 | [151] | ||
| NR1H | Nr1h2/Lxrβ | 1995 | [152] | Oxysterols and bile salts [78, 79] |
| Nr1h4/Fxrα | 1995 | [153] | ||
| Nr1h3/Lxrα | 1995 | [152] | ||