Figure 6.

Immune Parameter Changes during the First Weeks of Life

(A) The TDA parameter landscape subdivided into five developmental stages.

(B and C) Interindividual distances for plasma protein profiles (B) (Euclidean) and cell composition (C) (Atchinson’s) across the five stages.

(D) Plasma concentration (log₂ NPX) of cytokines IL-27 and IL-10.

(E) Plasma concentration (log₂ NPX) of PIgR.

(F) Plasma concentration (log₂ NPX) of IL-8 (CXCL8) and cytokines IL-17A and IL-12B.

(G) The frequency of CD8⁺ T cell cluster #1 as a fraction of all cells.

(H) bhSNE plots showing cluster localization among CD8⁺ T cells and CD3, CD8a, CD161, and CD38 expression. All p values from KS tests comparing distributions of stages 2–3 combined versus stage 5.

(I) Differentially regulated genes week 12 versus week 1 associated with the GO: positive reg. of immune system process. Genes ordered by absolute log₂ (week 12/week 1) (x axis) and actual log₂ (week 12/week 1) (y axis).

See also Figure S5 and Table S1.