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. 2018 Jul 23;126(7):077006. doi: 10.1289/EHP3441

Table 2.

Imprinted genetic loci with BPA-related DHMR.

Chr Start End Gene ID Gene Name Location Direction with BPA exposure csaw score FDR
chr2 174315451 174315750 14683 Gnas Intronic + 113.4 <0.001
chr11 12004801 12005100 14783 Grb10 Intronic + 70.5 <0.001
chr10 13130651 13131050 22634 Plagl1 Exonic + 60.7 <0.001
chr6 30957751 30958050 619665 Klf14 Exonic 55.9 <0.001
chr17 8746901 8747050 23984 Pde10a intronic + 50.1 <0.001
chr17 12828001 12828550 104103 Airn Intronic 16.2 0.02
chr13 24335001 24335150 12763 Cmah Intronic 13.1 0.05
chr7 60207401 60207600 20646 Snrpn Intronic 13.0 0.05
chr6 5079501 5079850 243725 Ppp1r9a Intronic 12.8 0.05
chr7 143348051 143348350 16535 Kcnq1 Intronic 11.5 0.07
chr10 13402051 13402250 215789 Phactr2 Intronic 11.3 0.07
chr13 108963951 108964200 238871 Pde4d Intronic + 10.1 0.10

Note: List of imprinted loci with annotated, significant (FDR<0.10) DHMRs generated from csaw modeling results. For csaw results, a transformed FDR is used for the score, such that score=10×log10(FDR); higher score indicates a larger degree of significance (lower FDR value). Additionally, direction of effect by BPA exposure is shown, with a (+) indicating increased 5-hmC with BPA exposure and a () indicating decreased 5-hmC with BPA exposure. BPA, bisphenol-A; Chr, chromosome; DHMR, differentially hydroxymethylated region; FDR, false discovery rate; ID, identification.