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. 2018 Jul 19;42(4):2020–2030. doi: 10.3892/ijmm.2018.3787

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Copyright: © Zou et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effects of MgiG on aminotransferases in serum and cell supernatants and histopathological alterations in hepatic tissues induced by oxaliplatin. (A) Levels of AST and ALT in cell supernatants following treatment of LO2 cells with oxaliplatin and MgiG. (B) Levels of AST and ALT in serum from mice treated with oxaliplatin and MgiG. (C) Representative images from hematoxylin and eosin staining of liver tissue sections from each experimental group, and scoring results for histopathologic grading. (D) Representative images from Sirius red staining of liver tissue sections and scoring results for collagen deposition. Data are presented as mean ± standard deviation (n=10 mice per group; n=3 for in vitro results). ^###P<0.001 compared with control; ^***P<0.001 compared with oxaliplatin alone. MgiG, magnesium isoglycyrrhizinate; AST, aspartate aminotransferase; ALT, aminotransferase; Oxa, oxaliplatin.

Effects of MgiG on aminotransferases in serum and cell supernatants and histopathological alterations in hepatic tissues induced by oxaliplatin. (A) Levels of AST and ALT in cell supernatants following treatment of LO2 cells with oxaliplatin and MgiG. (B) Levels of AST and ALT in serum from mice treated with oxaliplatin and MgiG. (C) Representative images from hematoxylin and eosin staining of liver tissue sections from each experimental group, and scoring results for histopathologic grading. (D) Representative images from Sirius red staining of liver tissue sections and scoring results for collagen deposition. Data are presented as mean ± standard deviation (n=10 mice per group; n=3 for in vitro results). ^###P<0.001 compared with control; ^***P<0.001 compared with oxaliplatin alone. MgiG, magnesium isoglycyrrhizinate; AST, aspartate aminotransferase; ALT, aminotransferase; Oxa, oxaliplatin.