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. 2018 Jul 19;42(4):2020–2030. doi: 10.3892/ijmm.2018.3787

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Copyright: © Zou et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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MgiG inhibits oxaliplatin-induced activation of the IL-6 pathway and the coagulation cascade. (A) Secreted levels and (B) mRNA expression levels of IL-6. (C) mRNA expression levels, and (D and E) protein expression levels of STAT3. (F) Secreted levels, (G) mRNA expression levels and (H and I) protein expression levels of vWF. (J) mRNA expression levels and (K and L) protein expression levels of PAI-1. Western blot results were normalized to GAPDH. Data are presented as mean ± standard deviation (n=10 mice per group; n=3 for in vitro results). ^###P<0.001 compared with control; ^**P<0.01 and ^***P<0.001 compared with oxaliplatin alone. MgiG, magnesium isoglycyrrhizinate; IL-6, interleukin-6; STAT3, signal transducer and activator of transcription 3; vWF, von Willebrand factor; PAI-1, plasminogen activator inhibitor-1; Oxa, oxaliplatin.

MgiG inhibits oxaliplatin-induced activation of the IL-6 pathway and the coagulation cascade. (A) Secreted levels and (B) mRNA expression levels of IL-6. (C) mRNA expression levels, and (D and E) protein expression levels of STAT3. (F) Secreted levels, (G) mRNA expression levels and (H and I) protein expression levels of vWF. (J) mRNA expression levels and (K and L) protein expression levels of PAI-1. Western blot results were normalized to GAPDH. Data are presented as mean ± standard deviation (n=10 mice per group; n=3 for in vitro results). ^###P<0.001 compared with control; ^**P<0.01 and ^***P<0.001 compared with oxaliplatin alone. MgiG, magnesium isoglycyrrhizinate; IL-6, interleukin-6; STAT3, signal transducer and activator of transcription 3; vWF, von Willebrand factor; PAI-1, plasminogen activator inhibitor-1; Oxa, oxaliplatin.