Table 3.

Fecundability odds ratios and 95% confidence intervals for preconception organophosphate and pyrethroid exposure ($n=615$).

Exposure ($\mathrm{\mu }\mathrm{g}/\mathrm{g}$ creatinine)	FOR (95% CI)
	All women ($n=615$)		Nulliparous women ($n=569$)
	Unadjusted	Adjustedb	Unadjusted	Adjustedb
OPs
DMP
Continuousa	0.97 (0.82, 1.15)	0.97 (0.82, 1.15)	0.97 (0.82, 1.15)	0.99 (0.83, 1.17)
Q1 ($\le 2.99$)	Reference	Reference	Reference	Reference
Q2 (2.99–6.99)	1.04 (0.78, 1.38)	1.03 (0.77, 1.37)	1.04 (0.78, 1.40)	1.02 (0.76, 1.38)
Q3 (6.99–16.14)	0.98 (0.73, 1.30)	0.93 (0.69, 1.24)	0.97 (0.72, 1.30)	0.91 (0.68, 1.24)
Q4 ($>16.14$)	0.88 (0.66, 1.18)	0.85 (0.63, 1.15)	0.90 (0.66, 1.29)	0.86 (0.64, 1.17)
p for trend	0.955	0.883	0.958	0.836
DMTP
Continuousa	1.09 (0.89, 1.33)	1.06 (0.86, 1.29)	1.08 (0.88, 1.33)	1.07 (0.97, 1.32)
Q1 ($\le 1.25$)	Reference	Reference	Reference	Reference
Q2 (1.25–2.79)	0.87 (0.65, 1.17)	0.91 (0.67, 1.23)	0.88 (0.65, 1.20)	0.90 (0.66, 1.23)
Q3 (2.79–5.97)	0.97 (0.73, 1.30)	0.97 (0.73, 1.30)	0.98 (0.72, 1.32)	0.97 (0.71, 1.31)
Q4 ($>5.97$)	1.12 (0.85, 1.49)	1.15 (0.86, 1.53)	1.17 (0.87, 1.32)	1.19 (0.89, 1.60)
p for trend	0.589	0.734	0.670	0.717
DEP
Continuousa	0.90 (0.68, 1.19)	0.90 (0.67, 1.20)	0.89 (0.67, 1.20)	0.91 (0.67, 1.23)
Q1 ($\le 5.86$)	Reference	Reference	Reference	Reference
Q2 (5.86–10.25)	1.04 (0.78, 1.40)	1.05 (0.78, 1.41)	1.06 (0.78, 1.43)	1.02 (0.75, 1.38)
Q3 (10.25–16.63)	1.11 (0.83, 1.47)	1.12 (0.84, 1.50)	1.08 (0.80, 1.46)	1.08 (0.80, 1.47)
Q4 ($>16.63$)	1.05 (0.78, 1.40)	1.08 (0.81, 1.45)	1.03 (0.76, 1.39)	1.04 (0.77, 1.41)
p for trend	0.635	0.601	0.997	0.778
DETP
Continuousa	1.07 (0.81, 1.41)	1.09 (0.82, 1.45)	1.07 (0.80, 1.43)	1.10 (0.82, 1.48)
Q1 ($\le 2.16$)	Reference	Reference	Reference	Reference
Q2 (2.16–3.47)	0.88 (0.66, 1.16)	0.85 (0.64, 1.13)	0.88 (0.66, 1.17)	0.83 (0.61, 1.11)
Q3 (3.47–6.43)	0.82 (0.62, 1.10)	0.84 (0.63, 1.12)	0.77 (0.57, 1.04)	0.78 (0.58, 1.06)
Q4 ($>6.43$)	0.71 (0.53, 0.95)*	0.68 (0.51, 0.92)*	0.71 (0.52, 0.96)*	0.67 (0.50, 0.91)*
p for trend	0.235	0.153	0.231	0.143
Total DAP
Continuousa	0.93 (0.69, 1.27)	0.94 (0.70, 1.26)	0.92 (0.68, 1.25)	0.95 (0.70, 1.28)
Q1 ($\le 108.5$)	Reference	Reference	Reference	Reference
Q2 (108.5–198.43)	1.06 (0.79, 1.42)	1.07 (0.80, 1.43)	1.06 (0.78, 1.43)	1.04 (0.77, 1.41)
Q3 (198.43–335.51)	0.96 (0.72, 1.29)	0.79 (0.58, 1.08)	0.94 (0.70, 1.28)	0.87 (0.64, 1.19)
Q4 ($>335.51$)	1.08 (0.81, 1.44)	0.90 (0.67, 1.21)	1.07 (0.79, 1.44)	1.03 (0.76, 1.39)
p for trend	0.874	0.988	0.914	0.873
PYR
3PBA
Continuousa	1.14 (0.88, 1.48)	1.19 (0.91, 1.54)	1.19 (0.91, 1.56)	1.23 (0.93, 1.61)
Q1 ($\le 0.44$)	Reference	Reference	Reference	Reference
Q2 (0.44–0.73)	0.86 (0.65, 1.14)	0.83 (0.62, 1.11)	0.82 (0.61, 1.11)	0.80 (0.60, 1.08)
Q3 (0.73–1.31)	0.88 (0.66, 1.17)	0.85 (0.63, 1.13)	0.84 (0.63, 1.12)	0.83 (0.62, 1.11)
Q4 ($>1.31$)	0.75 (0.56, 1.00)	0.77 (0.57, 1.03)	0.74 (0.54, 0.99)*	0.72 (0.53, 0.98)*
p for trend	0.216	0.160	0.121	0.089

Note: 3PBA, 3-phenoxybenzoic acid; CI, confidence interval; DAP, dialkyl phosphate; DEP, diethylphosphate; DETP, diethylthiophosphate; DMP, dimethylphosphate; DMTP, dimethylthiophosphate; FOR, fecundability odds ratio; OP, organophosphate; PYR, pyrethroid; Q1–4, quartiles 1–4.

^*$p<0.05$.

^aUrine concentrations of pesticide metabolites were adjusted for creatinine then ${\log }_{10}\text{-transformed}$.

^bAdjusted for age, prepregnancy body mass index (BMI), age at menarche, current smoking, education, annual household income, “Have you found that you could not cope with all the things that you had to do?”, and “How often have you been able to control irritations in your life?” in Cox models.