Table II.
Correlation between the risk score and clinical features.
| Variable | Total (n) (%) | Risk score of six-miRNA signature
|
χ2 test P-value |
|
|---|---|---|---|---|
| Low (n) (%) | High (n) (%) | |||
| Age (years) | ||||
| <60 | 125 (27.6) | 65 (52.0) | 60 (48.0) | 0.596 |
| ≥60 | 328 (72.4) | 162 (49.4) | 166 (50.6) | |
| Sex | ||||
| Male | 239 (52.8) | 121 (50.6) | 118 (49.4) | 0.294 |
| Female | 214 (47.2) | 106 (49.5) | 108 (50.5) | |
| TNM stage | ||||
| I+III | 250 (56.6) | 134 (53.6) | 116 (46.4) | 0.007 |
| III+IV | 192 (43.4) | 89 (46.4) | 103 (53.6) | |
| T-stage | ||||
| T1+T2 | 89 (19.6) | 55 (61.8) | 34 (38.2) | 0.070 |
| T3+T4 | 364 (80.4) | 172 (47.3) | 192 (52.7) | |
| N-stage | ||||
| N0 | 266 (58.7) | 140 (52.6) | 126 (47.4) | 0.007 |
| N1+N2 | 187 (41.3) | 87 (46.5) | 100 (53.4) | |
| M-stage | ||||
| M0 <0.001 | 332 (83.4) | 173 (52.2) | 159 (47.8) | |
| M1 | 64 (16.6) | 27 (42.2) | 37 (57.8) | |
| Residual tumor | ||||
| R0 | 327 (92.1) | 175 (53.5) | 152 (46.5) | 0.021 |
| R1+R2 | 28 (7.9) | 13 (46.4) | 15 (53.6) | |
The risk score was based on the 6-miRNA signature and the median was used as a cut-off to distinguish between high and low-risk. Values are expressed as n (%). a TNM, tumor-nodes-metastasis.