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. 2018 Jul 31;42(4):2098–2106. doi: 10.3892/ijmm.2018.3797

Figure 6.

Figure 6

Anti-apoptotic effect of PCSK9, involving a reduction in ApoER2 levels subsequent to MCAO in hyperlipidemic mice. (A) Immunohistochemistry analysis for ApoER2 in the hippocampus and cortex. (B) Gray value of ApoER2 in the hippocampus and cortex was higher in PCSK9 shRNA mice compared with that in HFD-MCAO mice. (C) Representative western blot images of ApoER2 and PCSK9 protein expression levels in the hippocampus and cortex following PCSK9 shRNA treatment. Relative protein levels of PCSK9 and ApoER2 were concomitantly decreased in the (D) hippocampus and (E) cortex following shRNA-PCSK9 interference. *P<0.05 and **P<0.01 vs. HFD-MCAO mice (n=4). PCSK9, proprotein convertase subtilisin/kexin type 9; ApoER2, apolipoprotein E receptor 2; shRNA, short hairpin RNA; HFD, high-fat diet; MCAO, middle cerebral artery occlusion.