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. 2018 Jul 18;42(4):1875–1884. doi: 10.3892/ijmm.2018.3782

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Copyright: © Go et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effect of piperlongumine (PL) on the phosphorylation of CREB in the hippocampus of aged mice. (A) Images showing anti-p-CREB antibody-stained CA1, CA3 and dentate gyrus (DG) of the hippocampus in aged mice treated with the vehicle or PL. Results of the quantitative analysis of the relative intensity of p-CREB in the (B) CA1, (C) CA3, and (D) DG of aged mice treated with the vehicle or PL (aged vehicle; n=5, aged PL; n=4). Scale bar, 200 μm. ^**P<0.01, significant differences from the aged vehicle, as shown by the Student's t-test. Data are presented as the means ± SEM.