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. 2018 Jul 18;42(4):1875–1884. doi: 10.3892/ijmm.2018.3782

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Copyright: © Go et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effect of piperlongumine (PL) on hippocampal neurogenesis. (A) Representative photomicrographs of the DG of the hippocampus of young control, aged vehicle and aged PL groups. Arrows indicate doublecortin (DCX)-positive cells. (B) The number of DCX-positive cells in the DG area of aged mice treated with the vehicle or PL and young mice (young control; n=5, aged vehicle; n=6, aged PL; n=9). Scale bar, 100 μm. ^*P<0.05 and ^**P<0.01, significant differences from an indicated group, determined by one-way ANOVA, followed by Tukey-Kramer's post-hoc test. Data are presented as the means ± SEM.