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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: J Autoimmun. 2018 Jun 28;93:57–65. doi: 10.1016/j.jaut.2018.06.003

Fig. 1.

Fig. 1

TRIF-deficiency protects NOD mice from diabetes development and is dependent on gut microbiota. The natural history of diabetes development was observed in female WT NOD and TRIF−/−NOD until 30–32 weeks. (A) Diabetes incidence of cohoused (mixed genotype) female WT NOD and TRIF−/−NOD littermates. (B) Diabetes incidence of non-cohoused (non-mixed genotype) female WT NOD and TRIF−/−NOD mice. Data were pooled from at least two independent experiments. Log-rank test for survival was used for analysis of diabetes incidence.