Table 2.

Treosulfan PK profile by BSA-based dosing groups

	Treosulfan dose (g/m2)
	10	12	14
N	5	10	4
PK Parameter
Age (years) *,+,#,‡	1 (0.9–1)	6 (4–8)	9 (9–11)
BSA (m2) *,+,#,‡	0.43 (0.38–0.50)	0.86 (0.52–0.99)	1.11 (1.05–1.40)
Weight (kg) *,+,#,‡	9.2 (8.1–14.6)	22.7 (19.4–25.1)	30.7 (30.1–37.5)
AUC (mcg/mL*h)†	2762 ± 1058	2240 ± 538	2235 ± 96
Cmax (mcg/mL)†	977 ± 412	799 ± 201	788 ± 28
t½ (h)†	1.39 ± 0.25	1.49 ± 0.14	1.38 ± 0.11
Vss (L) *,+,†	6.7± 2.3	9.5 ± 2.5	9.9 ± 0.6
CL (mL/min) *,+,†	69.4 ± 22.5	94.9 ± 18.2	104.5 ± 4.5

AUC: area under the curve; Cmax: maximum concentration; t^½: half-life; Vss: volume of distribution; CL: total clearance

^†AUC, Cmax, t^½Vss and CL expressed in mean + standard deviation (SD)

^‡Age, BSA and weight expressed in median (range)

^*,+,#Significant differences between BSA-based treosulfan doses (p < 0.05 (using t-test)):

^*10 vs.12 g/m²;

⁺10 vs.14 g/m²;

^#12 vs.14g/m²