Table 1:

miRNAs as Epigenetic Modifier in MDD-Suicide Brain

Study #	Brain areas	Participating miRNAs	Target Genes	References
1	Dorsolateral prefrontal cortex	miR-142-5p, miR-33a, miR-137, miR-489, miR-148b, miR-101, miR-324-5p, miR-301a, miR-146a, miR-335, miR-494, miR-20b, miR-376a*, miR-190, miR-155, miR- 660, miR-552, miR-453, miR-130a, miR-27a, miR-497, miR-10a, miR-20a, miR-142-3p	UBE2D1 and UBE2W, CAMK2G, AKAP1, SMAD5, MITF, BACH2, MYCN, GABRA4, and CACNA1C	Smalheiser et al., 2012
2	Frontal cortex	miR-185	TrkB.T1	Maussion et al., 2012
3	Prefrontal cortex	miR-139-5p, miR-320c, miR-34c-5p	SSAT1, SMOX	Lopez et al., 2014a
4	Prefrontal cortex	miR-1202	GRM4	Lopez et al., 2014b
5	Basolateral amygdala	miR-511	GFR1	Maheu et al., 2015
7	Edinger-Westphal nucleus (EWcp) of rostroventral midbrain area	miR-326	UCN1	Aschrafi et al., 2016
8	Prefrontal cortex	miR-218	Netrin-1 guidance cue receptor gene, deleted in colorectal cancer (DCC)	Torres-Berrio et al., 2017
9	Ventral prefrontal cortex	miR-146a-5p, miR-146b-5p, miR-425-3p, miR-24-3p	MAPK/WNT signaling pathway	Lopez et al., 2017
10	Locus coeruleus	miR-17-5p, miR-20b-5p, miR-106a-5p, miR-330-3p, miR- 409-5p, miR-541-3p, miR-582-5p, miR-890, let-7g-3p, miR-99b-3p, miR-550-5p, miR-1179	RELN, GSK-3β, MAOA, CHRM1, PLCB1 and GRIK1	Roy et al., 2017a
11	Prefrontal cortex	miR-19a-3p	TNF-α	Wang et al., 2018