Table 1.
Comparison of Demographics, Characteristics and Post-Transplant Survival Among Donors from Drug Overdose Versus All Other Causes
| Drug overdose (n = 15,359) | All other causes (n = 274,743) | P value | |
|---|---|---|---|
| Mean age (SD), year | 31.4 (10.1) | 38.5 (16.5) | < 0.001 |
| Ethnicity (%) | < 0.001 | ||
| Caucasian | 13,086 (85.2) | 184,730 (67.2) | < 0.001 |
| African-American | 853 (2.6) | 41,657 (15.2) | < 0.001 |
| Hispanic | 1127 (7.3) | 37,962 (13.8) | < 0.001 |
| Asian | 135 (0.9) | 6353 (2.3) | < 0.001 |
| Other | 158 (1.0) | 3998 (1.5) | < 0.001 |
| Gender (%) | < 0.001 | ||
| Female | 6475 (42.2) | 106,381 (38.7) | |
| Male | 8884 (57.8) | 168,361 (61.3) | |
| PHS/CDC high risk* (%) | 7602 (49.5) | 22,747 (8.3) | < 0.001 |
| HCV seropositive† (%) | 1584 (10.3) | 5827 (2.1) | < 0.001 |
| Mean cold ischemia time (SD), h | 3.9 (1.7) | 4.0 (1.7) | 0.156 |
| Donor organ type‡ (%) | |||
| Liver | 4541 (5.3%) | 81,798 (94.7%) | < 0.001 |
| Kidney | 7728 (5.3%) | 138,951 (94.7%) | < 0.001 |
| Heart | 1938 (6.1%) | 30,692 (93.9%) | < 0.001 |
| Lung | 1107 (4.5%) | 23,302 (95.5%) | < 0.001 |
| Liver | |||
| Liver donor risk index§ (SD) | 1.2 (0.3) | 1.4 (0.4) | < 0.001 |
| 1-year patient survival (95% CI), % | 91.4% (90.6–92.3) | 89.1 (88.9–89.3) | < 0.001 |
| Kidney | |||
| Kidney donor profile index‖ (SD) | 32.7 (19.9) | 48.7 (28.1) | < 0.001 |
| 1-year patient survival (95% CI), % | 96.4% (95.9–96.8) | 94.5% (94.9–95.1) | < 0.001 |
*Public Health Service/Center for Disease Control (PHS/CDC) high-risk donor for hepatitis C virus, human immunodeficiency virus, and hepatitis B virus infection
†Hepatitis C virus (HCV) antibody seropositive
‡Percentage of drug overdose or all other donors calculated by donor organ type
§Liver donor risk index (LDRI) score is a quantitative assessment of the risk of donor liver graft failure based on donor age, ethnicity, height, cause of death split or partial graft, cold ischemia time, and location of organs based on donor service area. LDRI score was provided by the United Network of Organ Sharing
‖Kidney donor profile index (KDPI) score is a quantitative assessment of the risk of donor kidney graft failure based on donor age, height, weight, ethnicity, cause of death, HCV serologic status, history of hypertension and diabetes, and serum creatinine. KDPI score was provided by the United Network of Organ Sharing