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. 2018 Aug 24;8:12756. doi: 10.1038/s41598-018-31190-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The loss of EfnB1 in osteoprogenitors alone induces an osteoporotic bone phenotype. (A–P) µCT analysis of the trabecular region of the (A–D) distal femoral and (I–L) fifth lumbar vertebral body of Osx:Cre (Osx) and EfnB1_OB^−/− (EfnB1) mice that had undergone sham or ovariectomy (OVX) surgery; represented as (A,I) Bone to tissue volume (BV/TV), (B,J) trabecular number (Tb.N), (C,K) trabecular separation (Tb.Sp) and (D,L) trabecular thickness (Tb.Th). (E–H,M–P) Representative images of 3D µCT from the (E–H) femur (in cross-sectional (top) and longitudinal (bottom) orientation) and (M–P) vertebral body of (E,G,M,O) sham and (F,H,N,P) ovariectomised (OVX) mice. All statistical analysis performed by 2-way ANOVA, multiple comparisons, n = 6–9 mice/condition/strain, *p < 0.05.