Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Aug 24;8:12756. doi: 10.1038/s41598-018-31190-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

The loss of EfnB1 by osteoprogenitors influences osteoclast formation and function. (A–D) Representative methacrylate embedded sections of the distal femora from (A,B) sham and (C,D) ovariectomised (OVX) (A,C) Osx:Cre (Osx) control and (B,D) EfnB1_OB^−/− (EfnB1) mice 12 weeks post-surgery stained with TRAP. (E,F) Histomorphometric analysis quantitating (E) the number of TRAP⁺ osteoclasts lining the bone perimeter, and (F) the percentage of osteoclast surface to bone surface within the trabecular region of the distal femora of Osx:Cre and EfnB1_OB^−/− sham and OVX mice (n = 4–5 samples/strain/condition). (G) Circulating collagen type I was measured by ELISA (n = 5–8 samples/strain/condition). All statistical analysis performed by 2-way ANOVA, multiple comparisons, *p ≤ 0.05. Magnification A–D = 10 µM.