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. 2018 Aug 24;8:12734. doi: 10.1038/s41598-018-31031-2

Figure 6.

Figure 6

Pharmacological inhibition of CcO using ADDA 5 sensitizes melanoma cells towards PTM induced cell death in 3D spheroids. (A) Metabolic activity of melanoma cells incubated with increasing concentrations of ADDA 5 (0.001, 0.01, 0.1 1 and 10 µM) in the presence or absence of PTM for 24 h. DMSO served as vehicle control. (B) Cytotoxicity of melanoma cells following ADDA 5 incubation in the presence or absence of PTM for 24 h. (C) Representative photomicrographs and quantification of 3D spheroids of SK-MEL-28 cells incubated with 1 µM of ADDA 5 in the presence or absence of PTM for 24 h. Scale bar: 250 µm. Data are mean + SEM from three independent experiments.