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. 2018 Aug 24;8:12815. doi: 10.1038/s41598-018-31153-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Evaluation of collagen IV and RI matching (a) Immunostained images of each organ with collagen IV, which is one of the main components for light scattering in tissues. (b) Correlation between the actual collagen amount and variation of transparency on different levels of RI-matching. Also see Suppl. Fig. 6. Average values of triplicated samples were used. (c) Maximum transparency of fully cleared tissue determined by contribution of RI-matching (ECM). (d) Finite-difference time-domain (FDTD) simulation with randomly generated images of various ECM density showing that light transmittance is dependent on ECM density (from negative slop of the linear fitting line) and ECM structures (from red points having similar ECM density).