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. 2018 Aug 24;8:12775. doi: 10.1038/s41598-018-30899-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Contextual fear extinction induces a shift from PSD-95-nNOS to PSD-95-TrkB coupling in the dorsal hippocampus. (A) Design of the experiments for (B–D). (B) Freezing behavior measured during extinction trial and retrieval of extinction memory (n = 6). (C) PSD-95-nNOS and PSD-95-TrkB complex levels in the dorsal hippocampus after contextual fear extinction. (PSD-95-nNOS: n = 5; PSD-95-TrkB: n = 5). (D) Design of the experiments for (E and F). (E) Freezing behavior measured during extinction trial from the mice with successful extinction and failured extinction (n = 5–6). (F) PSD-95-nNOS and PSD-95-TrkB complex level in the dorsal hippocampus after contextual fear extinction (PSD-95-nNOS: n = 5–6; PSD-95-TrkB: n = 5–6). (G) Design of the experiments for (H). (H) PSD-95-nNOS complex level in the dorsal hippocampus after recall (n = 3). Ext: extinction. Ext-S: extinction success. Ext-F: extinction failure.