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. 2018 Aug 24;8:12775. doi: 10.1038/s41598-018-30899-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PSD-95-nNOS blockers and NMDARs antagonists oppositely regulate BDNF expression. (A) Design of the experiments for (B,C). (B) Freezing behavior measured during extinction trial and retrial of extinction memory (n = 8). (C) Immunoblots showing BDNF expression in the dorsal CA3 after contextual fear extinction (n = 4). (D) Design of the experiments for (E–H). (E) Effect of intra-CA3 ZL006 on fear extinction (n = 12–13) and BDNF expression in the dorsal CA3 (n = 4). (F) Effect of LV-nNOS_1–133-GFP in the CA3 on fear extinction (n = 6) and BDNF expression in the dorsal CA3 (n = 3). (G) Effect of intra-CA3 MK801 on fear extinction (n = 12–14) and BDNF expression in the dorsal CA3 (n = 6–7). (H) Effect of intra-CA3 RO25-6981 on fear extinction (n = 12) and BDNF expression in the dorsal CA3 (n = 6). Ext: extinction. Con: fear conditioning.