Table 2.
Genotype distribution of the TLR3 SNPs and the association with spontaneous HBsAg seroclearance (SC) using logistic regression analysis.
| TLR3 | CHB (n = 621) | HBsAg SC (n = 239) | Unadjusted OR (CI 95%) | P-value | Adjusted OR (CI 95%) | P-value | |
|---|---|---|---|---|---|---|---|
| rs3775291 | GG | 248 (39.1%) | 124 (51.9%) | ||||
| AG | 236 (38.0%) | 92 (38.5%) | |||||
| AA | 137 (22.1%) | 23 (9.6%) | |||||
| MAF | 0.41 | 0.29 | |||||
| AA/AG vs. GG | 0.62 [0.46–0.83] | 0.002 | 0.58 [0.42–0.80] | 0.001 | |||
| AA vs. AG/GG | 0.38 [0.24–0.60] | 4.54 × 10−5 | |||||
| rs5743305 | TT | 207 (33.3%) | 102 (42.7%) | ||||
| AT | 304 (49.0%) | 108 (45.2%) | |||||
| AA | 110 (17.7%) | 29 (12.1%) | |||||
| MAF | 0.42 | 0.35 | |||||
| AA/AT vs. TT | 0.67 [0.50–0.91] | 0.011 | 0.66 [0.48–0.93] | 0.016 | |||
| AA vs. AT/TT | 0.64 [0.41–0.99] | 0.048 | |||||
CHB: chronic hepatitis B, SC: seroclearance, OR: odds ratio, CI: confidence interval.