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. 2018 Aug 24;8:12743. doi: 10.1038/s41598-018-31122-0

Figure 1.

Figure 1

(a) mtDNAcnres was negatively correlated with Clinical Global Impression - Severity (CGI-S) score (Spearman’s ρ = −0.152, p = 0.0006, n = 507). (b) mtDNAcnres correlated with the prescribed daily dose of clozapine (Spearman’s ρ = −0.351, p = 0.006, n = 61). (c) mtDNAcnres correlated with the prescribed daily dose of risperidone (Spearman’s ρ = −0.233 p = 0.026, n = 91). (d) Clozapine treatment, at 0.075 μM there was a 16% reduction in mtDNA copy number compared to vehicle treated cells (p = 0.0005), and at 0.75 μM there was a 25% reduction in mtDNA compared to vehicle treated cells (p = 0.0004). Risperidone treatment, at 0.025 μM there was no change in mtDNA copy number compared to vehicle treated cells, whereas at 0.25 μM there was a 14% reduction in mtDNA copy number compared to vehicle treated cells (p = 0.0126). Error bars indicate standard error. R.Q.: relative quantification (mtDNA copy number). *p < 0.05; ***p < 0.001.