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. 2018 Aug 24;8:12774. doi: 10.1038/s41598-018-31149-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ZIKV infection alters cerebral cortex angiogenesis proteins levels. Cerebral cortex tissue extracts from three E15.5 embryos from three different litters of each experimental group were evaluated by angiogenesis proteomic profile. From 53 possible angiogenesis-related proteins, we identified 47 both present in MOCK and ZIKV infected brains (A). ZIKV infection increased the levels of 45 molecules (B). Besides their previously described role on angiogenesis, many identified proteins also contribute to other biological processes (C), including neurogenesis (19.66%), cell migration (16.85%), CNS development (7.87%) and inflammatory responses (8.43%).