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. Author manuscript; available in PMC: 2018 Aug 25.
Published in final edited form as: Cell Rep. 2018 Jul 3;24(1):259–268.e3. doi: 10.1016/j.celrep.2018.06.022

Figure 5. Ab Initio Structures from a Cellular Fraction Unambiguously Reveal the Proteasome.

Figure 5.

(A) Reference-free 2D class averages of the proteasome from Figure 3B.

(B) Top: structure of single-capped proteasome generated using RELION from manually picked particles. Bottom: ab initio structure of the 20S core proteasome generated using cryoSPARC is shown. High-resolution structures EMD-4002 (Schweitzer et al., 2016) and EMD-2981 (da Fonseca and Morris, 2015) are fit into the structures, respectively.

See also Figures S4 and S5.