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. 2018 Aug 25;18:7. doi: 10.1186/s12907-018-0074-3

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 9 — Differential diagnosis between particle laden macrophagic infiltrate and other macrophagic diseases in bone. a Implant aseptic loosening (osteolysis). Dense macrophage infiltrate in the bone marrow in a MoP THA implant (H&E × 200) containing birefringent PE microparticles under polarized light in inset (× 400). b Implant aseptic loosening (osteolysis). Diffuse, brownish macrophage infiltrate containing tribocorrosion and conventional metallic particles in a femoral head of a MoM HRA implant (H&E × 200). c Gaucher’s disease. Macrophage infiltrate in the bone marrow of a femoral head (H&E × 200) with details of the macrophage crumpled cytoplasm in inset (H&E × 400). d Erdheim-Chester disease. Bone marrow from proximal tibia with foamy macrophages and mixed chronic inflammatory infiltrate (H&E × 200) and mixed chronic inflammatory infiltrate and adjacent sclerotic cancellous bone with osteoblastic rimming in inset (H&E × 400)