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. 2018 Aug 25;7:131. doi: 10.1186/s13643-018-0779-5

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Schema illustrating calculation of mean between-group difference in blood pressure. Hypothetical data are presented. In this example, the mean between-group difference in blood pressure would be (195–185) − (195–170) = 10–25 = − 15 mmHg. That is, the intervention drug reduced blood pressure, on average, by 15 mmHg more than the control drug (placebo or active comparator)