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. 2018 Aug 24;18:422. doi: 10.1186/s12879-018-3348-6

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Gene expression of whole blood leukocytes in patients with RR as compared to patients without leprosy reactions. A group of genes differentially expressed in RR samples was identified, consisting of 1 chemokine gene (CCL2 logFC = 4.04), 2 PARK genes (PARK logFC =3.27, LRRK2 logFC =3.09), 1 eicosanoid metabolism gene (ALOX5 logFC =2.99), 4 pattern recognition receptor genes (Toll-like receptors -TLRs: TLR7 logFC =2.98, TLR10 logFC =3.07, TLR3 logFC =2.74, and C-lectin receptors-CLRs: CLEC5A logFC =2.81), 2 cytokine genes (IL18 logFC =2.34, IL15 logFC = 2.42) and 2 type I IFN genes (IFNB logFC =2.36, OAS1 logFC = 2.51)