Table 2.
Normalized gene expression values of whole blood leukocytes samples of leprosy patients with reactions (n = 94) and leprosy patients without reactions (n = 57)
| Reaction vs No Reaction | |||
|---|---|---|---|
| Gene | Description | log fold change | p.value* |
| CCL2 | C-C Motif Chemokine Ligand 2 | 4.04 | 0.0016 |
| PARK | parkinson protein 2, E3 ubiquitin protein ligase | 3.27 | 0.0036 |
| ALOX5 | Arachidonate 5-Lipoxygenase | 2.99 | 0.0108 |
| TLR7 | Toll Like Receptor 7 | 2.98 | 0.011 |
| LRRK2 | Leucine Rich Repeat Kinase 2 | 3.09 | 0.0161 |
| IFNB | interferon beta 1 | 2.36 | 0.0228 |
| TLR10 | Toll Like Receptor 10 | 3.07 | 0.0236 |
| IL18 | Interleukin 18 | 2.34 | 0.0326 |
| TLR3 | Toll Like Receptor 3 | 2.74 | 0.0338 |
| CLEC5A | C-Type Lectin Domain Containing 5A | 2.81 | 0.0446 |
| RR vs No Reaction | |||
| CCL2 | C-C Motif Chemokine Ligand 2 | 4.31 | 0.0002 |
| TLR7 | Toll Like Receptor 7 | 3.81 | 0.0012 |
| PARK | parkinson protein 2, E3 ubiquitin protein ligase | 3.16 | 0.002 |
| ALOX5 | Arachidonate 5-Lipoxygenase | 3.32 | 0.0044 |
| LRRK2 | Leucine Rich Repeat Kinase 2 | 3.28 | 0.0056 |
| IFNB | interferon beta 1 | 2.64 | 0.0104 |
| TLR10 | Toll Like Receptor 10 | 3.08 | 0.0122 |
| TLR3 | Toll Like Receptor 3 | 3.04 | 0.0122 |
| IL18 | Interleukin 18 | 2.65 | 0.014 |
| OAS1 | 2′-5′-oligoadenylate synthetase 1 | 2.51 | 0.0376 |
| IL15 | Interleukin 15 | 2.42 | 0.0446 |
| ENL vs No Reaction | |||
| PARK | parkinson protein 2, E3 ubiquitin protein ligase | 2.13 | 0.0436 |
| ENL vs RR | |||
| TLR7 | Toll Like Receptor 7 | −2.72 | 0.0214 |
*The genes were defined as differentially expressed by the criterion of p-value adjusted for multiple comparisons. Bayesian statistical analysis used a log fold change cutoff of > 1 and adjusted p value of < 0.05. - Abbreviations: RR reversal reaction, ENL erythema nodosum leprosum