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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Prog Biophys Mol Biol. 2018 May 24;137:95–110. doi: 10.1016/j.pbiomolbio.2018.05.005

Figure 3. Surgical Manipulations.

Figure 3

Illustrations of (A) VVL in an HH17 avian embryo (B) LAL in an HH21 avian heart, (C) OTB in an HH18 avian heart, (D) microbead outflow occlusion and (E) microbead inflow occlusion in a 57 hpf zebrafish heart. See Table 1 for staging details. Illustrations adapted from Midgett 2014 and Hove et al 2003, with reference to videos from (Al Naieb et al., 2013). Blue shapes indicate sutures/clips/beads, red lines indicate blood flow. A lone bar-headed line indicates complete occlusion (A,D, and E) and a bar-headed line paired with a dashed arrow-headed line (B, C) indicates partial occlusion and perturbed flow. H: heart, E: eye, AVC: atrioventricular canal, OFT: outflow tract, V: ventricle, RA: right atrium, LA: left atrium, SV: sinus venosis, A: atrium.