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. 2018 Aug 8;2018:6984948. doi: 10.1155/2018/6984948

Figure 2.

Figure 2

Illustrative image describing anti-PD-1/PD-L1 therapy combined with CAR-T cells. T cells are obtained and isolated from the patients. These T cells are transformed with chimeric antigen receptor (CAR) gene by lentiviruses. The CAR-T cells are expanded in vitro and finally infused back to patients. After the CAR-T cells transferred into patients, the CAR-T cells are able to recognize target gene-positive tumor cells. Meanwhile, CAR-T cells can secrete anti-PD-1/PD-L1 antibody and combine with foreign anti-PD-1/PD-L1 antibody to recognize and kill the tumor cells.