Table 3.
Studies from the literature assessing the recurrence pattern after curative intent surgery for perihilar cholangiocarcinomas.
| Author, year | Number of patients resected for PHC | Median follow-uptime (months) | Median disease-freesurvival (months) | Overall recurrence observed during follow-up time (%) | Recurrence rate at 5 years | Isolated local recurrence rate (%) | Distant metastases at the first recurrence (%) | Death observed during follow-uptime (%) | Recurrence as cause of death (% of total deaths) |
|---|---|---|---|---|---|---|---|---|---|
| Jarnagin et al. [11], 2003 | 76 | 24 months | NA | 68% | NA | NA | 36% | NA | NA |
| Ito et al. [10], 2008 | 38 | 29 months | 31 months | 65.8% | NA | NA | 42.1% | NA | NA |
| Chen et al. [8], 2009 | 138 | 33 months | NA | 49.3% | NA | NA | 45.7% | NA | NA |
| Kobayashi et al. [14], 2010 | 79 | 30 months | NA | 53% | NA | NA | 43% | NA | NA |
| Saxena et al. [15], 2011 | 42 | 20 months | 15 months | 64% | 88% | NA | NA | 60% | NA |
| Wahab et al. [22], 2012 | 159 | 27 months | NA | 59.1% | NA | NA | NA | NA | NA |
| Nuzzo et al. [21], 2012, multicentric | 440 | NA | NA | 54.5% | NA | NA | NA | NA | NA |
| Groot et al. [9], 2015, multicentric | 306 | 48 months | 26 months | 58% | 67% | 18% | 40% | 70% | 91% |
| Kang et al. [13], 2016 | 260 | 102 months | NA | 55% | NA | NA | 39.7% | NA | NA |
| Komaya et al. [7], 2018 | 402 | 43 months | NA | 61.7% | 71.4% | 19.1% | 45.8% | 64.9% | NA |
| Zhang et al. [17], 2018, multicentric | 225 | 18 months | NA | 44% | 70.5% | NA | NA | NA | NA |
| Present series, 2018 | 139 | 89 months | 21 months | 61.9% | 68% | 2.2% | 59.7% | 71.9% | 83% |