Table III.
Antimicrobial Susceptibilities of Isolates
| ALL INFANTS12 | |||
|---|---|---|---|
| Antimicrobial(s) | Total N (%)3 | Bacteremia without meningitis N (%) |
Bacterial Meningitis4 N (%) |
| Individual | |||
| Ampicillin | 306/429 (71.3) | 233/344 (67.7) | 73/85 (85.9) |
| 3rd generation cephalosporin | 388/435 (89.2) | 309/349 (88.5) | 79/86 (91.9) |
| Combination | |||
| Ampicillin/gentamicin | 411/428 (96.0)5 | 338/343 (98.5) | 73/85 (85.9)5 |
| Ampicillin/3rd generation cephalosporin | 422/436 (96.8) | 337/350 (96.3) | 85/86 (98.8) |
| Vancomycin/ampicillin/gentamicin | 429/434 (98.9)5 | 345/349 (98.9) | 84/85 (98.8)5 |
| Vancomycin/3rd generation cephalosporin | 424/432 (98.2) | 341/348 (98.0) | 83/84 (98.8) |
| INFANTS ≤28 DAYS OF AGE2 | |||
| Antimicrobial(s) | Total N (%)3 | Bacteremia without meningitis N (%) | Bacterial Meningitis4 N(%) |
| Individual | |||
| Ampicillin | 152/229 (66.4) | 105/173 (60.7) | 47/56 (83.9) |
| 3rd generation cephalosporin | 202/229 (88.2) | 151/173 (87.3) | 51/56 (91.1) |
| Combination | |||
| Ampicillin/gentamicin | 217/228 (95.2)5 | 170/172 (98.8) | 47/56 (83.9)5 |
| Ampicillin/3rd generation cephalosporin | 224/230 (97.4) | 168/174 (96.6) | 56/56 (100) |
| Vancomycin/ampicillin/gentamicin | 227/230 (98.7)5 | 172/174 (98.9) | 55/56 (98.2)5 |
| Vancomycin/3rd generation cephalosporin | 225/227 (99.1) | 171/173 (98.8) | 54/54 (100) |
| INFANTS 29–60 DAYS OF AGE2 | |||
| Antimicrobial(s) | Total N (%)3 | Bacteremia without meningitis N (%) | Bacterial Meningitis4 N(%) |
| Individual | |||
| Ampicillin | 154/200 (77.0) | 128/171 (74.9) | 26/29 (89.7) |
| 3rd generation cephalosporin | 186/206 (90.3) | 158/176 (89.8) | 28/30 (93.3) |
| Combination | |||
| Ampicillin/gentamicin | 194/200 (97.0)5 | 168/171 (98.3) | 26/29 (89.7)5 |
| Ampicillin/3rd generation cephalosporin | 198/206 (96.1) | 169/176 (96.0) | 29/30 (96.7) |
| Vancomycin/ampicillin/gentamicin | 202/204 (99.0)5 | 173/175 (98.9) | 29/29 (100)5 |
| Vancomycin/3rd generation cephalosporin | 199/205 (97.1) | 170/175 (97.1) | 29/30 (96.7) |
1
5 infants had missing antimicrobial susceptibilities (3 with bacteremia without meningitis, 2 with bacterial meningitis)
2
Denominators represent infants with available susceptibility testing
3
N (%) susceptible
4
Infants with bacterial meningitis with or without bacteremia
5
Gentamicin has poor cerebrospinal fluid penetration; pathogen considered ampicillin/gentamicin resistant if infant had bacterial meningitis and pathogen was ampicillin-resistant