Table 2.

Effect of the LCT variant on 2-year changes in body composition and body fat distribution in response to low/high protein diet

	Low-protein diet		High-protein diet		Pinteraction
	β (SE)	P	β (SE)	P
Model 1
ΔWhole body total fat mass %	0.79 (0.62)	0.21	–0.77 (0.43)	0.07	0.03
ΔTrunk fat %	1.23 (0.78)	0.12	–0.89 (0.56)	0.12	0.03
ΔDeep subcutaneous adipose tissue mass, DSAT	0.47 (0.3)	0.13	–0.19 (0.22)	0.4	0.08
ΔSuperficial adipose tissue mass, SAT	1.46 (0.49)	0.006	–0.62 (0.38)	0.11	0.005
ΔVisceral adipose tissue mass, VAT	0.32 (0.36)	0.38	–0.58 (0.26)	0.03	0.04
ΔTotal adipose tissue mass, TAT	1.9 (0.74)	0.02	–1.17 (0.68)	0.09	0.005
Model 2
ΔWhole body total fat mass %	0.73 (0.63)	0.25	–0.9 (0.43)	0.04	0.03
ΔTrunk fat %	1.17 (0.79)	0.14	–1.06 (0.58)	0.07	0.02
ΔDSAT	0.28 (0.3)	0.37	–0.16 (0.23)	0.49	0.13
ΔSAT	1.05 (0.54)	0.06	–0.89 (0.42)	0.04	0.004
ΔVAT	0.15 (0.35)	0.68	–0.63 (0.27)	0.03	0.04
ΔTAT	1.3 (0.84)	0.14	–1.69 (0.76)	0.03	0.005

β represents changes in outcomes for the increasing number of the G allele of LCT SNP rs4988235.

Model 1: age, sex, body mass index at the baseline examination, and variable of interest at the baseline examination.

Model 2: age, sex, body weight, diastolic blood pressure, and log-transformed triglycerides, and variable of interest at the baseline examination.