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Daily body weight (A) and food intake (B) of rats receiving fourth-ventricle infusions of leptin. Pumps were attached to the cannulas on day 0, and the rats also received third-ventricle injections of 0.1 μg leptin on days 9 and 13 of infusion. *Significant difference between rats receiving infusions of 0.6 μg leptin/day and those infused with 0.01 μg leptin/day. #Significant difference between rats infused with 0.06 μg leptin/day and those infused with saline.
