Table 1.
Subtypes of B-NHL in the order of B-cell development
| B-cell non-Hodgkin lymphoma (B-NHL) subtype | Subgroup | Reference | Cell of origin
|
Molecular features
|
Incidence
|
|||
|---|---|---|---|---|---|---|---|---|
| B-cell type | Localization | Translocation | Oncogene | Per 105 person-years37 | % of B-NHL | |||
| B-cell acute lymphoblastoid leukemia (B-ALL) | 38 | Immature | BM | t(9;22) | BCR-ABL | 0.8 | 2.9 | |
| Mature | Periphery | |||||||
| Mantle-cell lymphoma (MCL) | 39 | Naïve | LN or S | t(11;14) | Cyclin D1 | 0.5 | 2.0 | |
| Chronic lymphocytic leukemia (CLL) | UM | 1 | Follicular | LN or S | ZAP70 | 5.2 | 19.8 | |
| M | Memory | |||||||
| Marginal-zone lymphoma (MZL) | 40 | Follicular | LN or S | 1.0 | 3.7 | |||
| Follicular lymphoma (FL) | 41, 42 | Centrocyte | GC | t(14;18) | BCL2 | 3.2 | 12.2 | |
| Burkitt lymphoma (BL) | 43 | Follicular | GC | t(8;14) | MYC | 0.3 | 1.1 | |
| Diffuse large B-cell lymphoma (DLBCL) | GC | 44, 45 | Centroblast | GC | PTEN loss | 7.1 | 27.3 | |
| ABC | Plasmablast | GC | Mutant CD79, CARD11, MYD88 | |||||
| Waldenström macroglobulinemia (WM) | 46 | B cells to plasma cells | BM | MYD88 L265P | 0.4 | 1.3 | ||
| Multiple myeloma (MM) | 47 | Plasma cell | BM | 5.3 | 20.2 | |||
Notes: B-NHL subtypes listed according to development stages of presumed cells of origin; references to recent reviews of diseases included, along with indications of molecular features and incidence.
Abbreviations: ABC, activated B cell; BM, bone marrow; GC, germinal center; LN, lymph node; M, mutated IGHV genes; MZ, marginal zone; S, spleen; UM, unmutated IGHV genes.