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. 2018 Aug 16;9:1881. doi: 10.3389/fimmu.2018.01881

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Copyright © 2018 Feng, Yao, Zhou, Xia, Lyu, Li, Zhao, Zhang, Zhao and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The protective effects of ARC on liver pathology of ConA-induced hepatitis mice. ARC or vehicle alone had no effects on morphology of liver section (A,B). Serious liver damage was found in model group at 12 h after ConA (10 mg⋅kg⁻¹) administration (C). Portal inflammation, hepatocytes edema, severe congestion in hepatic sinusoid around central veins, and focal or confluent necrosis occurred significantly. ARC significantly inhibited ConA-induced histological changes, which was comparable with effects of CSA and PS (D–F).