Table 2.
Protein changes in mice liver following ConA exposure for 12 h.
| UniProt ID | Gene name | Protein description | Fold-change |
|---|---|---|---|
| ConA/Normal saline | |||
| E9Q4J9 | Adgrf2 | Adhesion G-protein coupled receptor F2 | 16.37 |
| Q8CEE6 | Pask | PAS domain-containing serine/threonine-protein kinase | 10.94 |
| Q9JKV1 | Adrm1 | Proteasomal ubiquitin receptor ADRM1 | 7.91 |
| P50247 | Ahcy | Adenosylhomocysteinase | 6.93 |
| Q9QZU9 | Ube2l6 | Ubiquitin/ISG15-conjugating enzyme E2 L6 | 5.99 |
| P62874 | Gnb1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 5.33 |
| P50283 | Cd7 | T-cell antigen CD7 | 4.75 |
| Q64339 | Isg15 | Ubiquitin-like protein ISG15 | 4.66 |
| O08601 | Mttp | Microsomal triglyceride transfer protein large subunit | 4.57 |
| Q9QUJ7 | Acsl4 | Long-chain-fatty-acid—CoA ligase 4 | 4.18 |
| Q8R3B1 | Plcd1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 | 4.16 |
| Q0KK56 | Fam184b | Protein FAM184B | 3.62 |
| Q03963 | Eif2ak2/Pkr | Interferon-induced, double-stranded RNA-activated protein kinase | 3.59 |
| Q8BQZ5 | Cpsf4 | Cleavage and polyadenylation specificity factor subunit 4 | 3.54 |
| P10126 | Eef1a1 | Elongation factor 1-alpha 1 | 3.53 |
| P56380 | Nudt2 | Bis(5’-nucleosyl)-tetraphosphatase [asymmetrical] | 3.42 |
| P28740 | Kif2a | Kinesin-like protein KIF2A | 3.35 |
| Q5SWU9 | Acaca | Acetyl-CoA carboxylase 1 | 3.04 |
| Q60936 | Adck3 | Atypical kinase COQ8A, mitochondrial | 2.99 |
| Q9QYJ3 | Dnajb1 | DnaJ homolog subfamily B member 1 | 2.89 |
| P42225 | Stat1 | Signal transducer and activator of transcription 1 | 2.79 |
| P35583 | Foxa2 | Hepatocyte nuclear factor 3-beta | 2.78 |
| P23506 | Pcmt1 | Protein-l-isoaspartate (d-aspartate) O-methyltransferase | 2.76 |
| P32233 | Drg1 | Developmentally regulated GTP-binding protein 1 | 2.74 |
| Q8VI93 | Oas3 | 2′-5′-oligoadenylate synthase 3 | 2.67 |
| Q9D906 | Atg7 | Autophagy-related protein 7 | 2.63 |
| Q64112 | Ifit2 | Interferon-induced protein with tetratricopeptide repeats 2 | 2.46 |
| Q99LC5 | Etfa | Electron transfer flavoprotein subunit alpha | 2.45 |
| Q9JII1 | Inpp5e | 72 kDa inositol polyphosphate 5-phosphatase | 2.39 |
| O08788 | Dctn1 | Dynactin subunit 1 | 2.35 |
| P01887 | B2m | Beta-2-microglobulin | 2.34 |
| P02469 | Lamb1 | Laminin subunit beta-1 | 2.18 |
| O88587 | Comt | Catechol O-methyltransferase | 2.17 |
| Q8K298 | Anln | Anillin | 2.13 |
| Q01514 | Gbp1 | Guanylate-binding protein 1 | 2.08 |
| P09922 | Mx1 | Interferon-induced GTP-binding protein Mx1 | 2.04 |
| P14869 | Rplp0 | 60S acidic ribosomal protein P0 | 1.98 |
| Q02395 | Mtf2 | Metal-response element-binding transcription factor 2 | 1.98 |
| Q9ESY9 | Ifi30 | Gamma-interferon-inducible lysosomal thiol reductase | 1.97 |
| Q9JL16 | Isg20 | Interferon-stimulated gene 20 kDa protein | 1.88 |
| Q64345 | Ifit3 | Interferon-induced protein with tetratricopeptide repeats 3 | 1.63 |
| P02535 | Krt10 | Keratin, type I cytoskeletal 10 | 0.55 |
| Q8R5M2 | Wnt9a | Protein Wnt-9a | 0.49 |
| Q9WVR4 | Fxr2 | Fragile X mental retardation syndrome-related protein 2 | 0.47 |
| Q99LB7 | Sardh | Sarcosine dehydrogenase, mitochondrial | 0.44 |
| Q61166 | Mapre1 | Microtubule-associated protein RP/EB family member 1 | 0.39 |
| F8WJD4 | Sympk | Symplekin | 0.39 |
| Q99LD4 | Gps1 | COP9 signalosome complex subunit 1 | 0.38 |
| P68373 | Tuba1c | Tubulin alpha-1C chain | 0.36 |
| Q8BTI8 | Srrm2 | Serine/arginine repetitive matrix protein 2 | 0.34 |
| Q8BHN3 | Ganab | Neutral alpha-glucosidase AB | 0.33 |
| P19096 | Fasn | Fatty acid synthase | 0.29 |
| P16675 | Ctsa | Lysosomal protective protein | 0.23 |
| P01845 | Iglc3 | Ig lambda-3 chain C region | 0.21 |
| P29758 | Oat | Ornithine aminotransferase, mitochondrial | 0.18 |
| Q99JZ7 | Errfi1 | ERBB receptor feedback inhibitor 1 | 0.09 |
| P50446 | Krt6a | Keratin, type II cytoskeletal 6A | 0.08 |
Table showed the mean fold changes of proteins in model mice versus normal mice with p values less than 0.05 (n = 3), where ratios >1.25 were upregulation; ratios <0.8 were downregulation.