Table 4.
Protein changes in mice liver tissues with or without ARC pretreatments following ConA exposure for 12 h.
| UniProt ID | Gene name | Protein description | Fold-change |
|---|---|---|---|
| ConA + ARC/ConA + vehicle | |||
| E9Q4J9 | Adgrf2 | Adhesion G-protein coupled receptor F2 | 0.09 |
| Q8CEE6 | Pask | PAS domain-containing serine/threonine-protein kinase | 0.13 |
| Q9JKV1 | Adrm1 | Proteasomal ubiquitin receptor ADRM1 | 0.18 |
| P50247 | Ahcy | Adenosylhomocysteinase | 0.21 |
| Q9QZU9 | Ube2l6 | Ubiquitin/ISG15-conjugating enzyme E2 L6 | 0.23 |
| P50283 | Cd7 | T-cell antigen CD7 | 0.29 |
| Q64339 | Isg15 | Ubiquitin-like protein ISG15 | 0.32 |
| Q9QUJ7 | Acsl4 | Long-chain-fatty-acid—CoA ligase 4 | 0.33 |
| Q8R3B1 | Plcd1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 | 0.34 |
| Q03963 | Eif2ak2/Pkr | Interferon-induced, double-stranded RNA-activated protein kinase | 0.39 |
| P10126 | Eef1a1 | Elongation factor 1-alpha 1 | 0.43 |
| P56380 | Nudt2 | Bis(5′-nucleosyl)-tetraphosphatase [asymmetrical] | 0.41 |
| P28740 | Kif2a | Kinesin-like protein KIF2A | 0.42 |
| Q5SWU9 | Acaca | Acetyl-CoA carboxylase 1 | 0.46 |
| Q9QYJ3 | Dnajb1 | DnaJ homolog subfamily B member 1 | 0.48 |
| P42225 | Stat1 | Signal transducer and activator of transcription 1 | 0.57 |
| P35583 | Foxa2 | Hepatocyte nuclear factor 3-beta | 0.55 |
| P23506 | Pcmt1 | Protein-l-isoaspartate (d-aspartate) O-methyltransferase | 0.51 |
| P32233 | Drg1 | Developmentally-regulated GTP-binding protein 1 | 0.51 |
| Q8VI93 | Oas3 | 2′-5′-oligoadenylate synthase 3 | 0.52 |
| Q9D906 | Atg7 | Autophagy-related protein 7 | 0.53 |
| Q64112 | Ifit2 | Interferon-induced protein with tetratricopeptide repeats 2 | 0.57 |
| Q99LC5 | Etfa | Electron transfer flavoprotein subunit alpha | 0.57 |
| O08788 | Dctn1 | Dynactin subunit 1 | 0.61 |
| P01887 | B2m | Beta-2-microglobulin | 0.64 |
| P02469 | Lamb1 | Laminin subunit beta-1 | 0.64 |
| O88587 | Comt | Catechol O-methyltransferase | 0.65 |
| Q01514 | Gbp1 | Guanylate-binding protein 1 | 0.67 |
| P09922 | Mx1 | Interferon-induced GTP-binding protein Mx1 | 0.69 |
| Q02395 | Mtf2 | Metal-response element-binding transcription factor 2 | 0.71 |
| Q9ESY9 | Ifi30 | Gamma-interferon-inducible lysosomal thiol reductase | 0.71 |
| Q9JL16 | Isg20 | Interferon-stimulated gene 20 kDa protein | 0.74 |
| Q64345 | Ifit3 | Interferon-induced protein with tetratricopeptide repeats 3 | 0.76 |
| Q99LD4 | Gps1 | COP9 signalosome complex subunit 1 | 1.88 |
| P68373 | Tuba1c | Tubulin alpha-1C chain | 1.98 |
| Q8BHN3 | Ganab | Neutral alpha-glucosidase AB | 2.16 |
| P19096 | Fasn | Fatty acid synthase | 2.46 |
| P16675 | CtsA | Lysosomal protective protein | 3.11 |
| P01845 | Iglc3 | Ig lambda-3 chain C region | 3.41 |
| Q99JZ7 | Errfi1 | ERBB receptor feedback inhibitor 1 | 7.94 |
Table showed the mean fold changes of proteins in ARC pre-treated model group verses vehicle group with p values less than 0.05 (n = 3), where ratios >1.25 were upregulation; ratios <0.8 were downregulation.