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. 2018 Aug 17;9:1734. doi: 10.3389/fmicb.2018.01734

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Copyright © 2018 Joslyn, Pienaar, DiFazio, Suliman, Kagina, Flynn, Scriba, Linderman and Kirschner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Experimental data show different responses to ESAT6 antigen following H56 vaccination. The percentage of blood CD4+ T cells that respond to ESAT6 by producing cytokines (cytokine+) is divided by the total number of CD4+ T cells in the blood. T cell subtypes are also shown. Each time point shows the responses of all 8 human (red) or all 8 NHPs (blue) subjects. Note that it can be difficult to perceive 8 individual dots–if the subject's responses are similar or the same, as individual dots overlap. For ease of comparison, we have placed both panels of data on the same y-axis. Arrows represent vaccination timepoints.