Table 1.

Parameters with significant PRCCs for ESAT6 immune response outcomes.

ESAT6	Central memory	Effector	Effector memory
NHP	central memory reactivation rate; precursor proliferation and differentiation into central memory cells; APC and precursor death rates	precursor proliferation and differentiation into effector cells; effector, APC, and precursor death rates	precursor proliferation and differentiation into effector cells; APC and precursor death rates
Human	Likelihood of proliferation; precursor proliferation and differentiation to central memory; central memory recruitment; APC, and precursor death rates;	Likelihood of proliferation and differentiation; Naïve T cell recruitment; Precursor proliferation and differentiation to Effector; effector differentiation to effector Memory; effector Lymph efflux; effector, APC, and precursor death rates;	Likelihood of proliferation and differentiation; precursor proliferation; effector memory, APC, and precursor death rates;

One row displays humans, the other displays NHPs. Columns list the 3 model outcomes of interest – ESAT6-specific central memory, effector and effector memory T cell phenotypes. These outcomes were selected for analysis because the model was calibrated to their dataspace. Each table cell contains a general description of significant (i.e., p < 10⁻³) parameters with respect to each output of the model.