Table 2.
Initial conditions represent the difference in BCG timing between experimental protocols.
| Initial condition of cell type | ESAT6 | Ag85b | |||||
|---|---|---|---|---|---|---|---|
| NHP | Human | NHP | Human | ||||
| Units | Range of values | Range of values | Range of values | Range of values | |||
| Naïve CD4+ specific Blood T cells | cell/mm3 | (0.1,0.25) | (0.07, 0.6) | (0.17,0.37) | (0.04,0.27) | ||
| Effector CD4+ specific Blood T cells | cell/mm3 | (0.001,1.5) | 0 | (0.001,2.5) | 0 | ||
| Central Memory CD4+ specific Blood T cells | cell/mm3 | (0.0015,0.006) | (0.00002, 0.03) | (0.002,0.2) | (0.02,0.3) | ||
| Effector Memory CD4+ specific Blood T cells | cell/mm3 | (0.001,0.5) | (0.003, 0.15) | (0.003, 0.9) | (0.0016,2.6) | ||
| Naïve CD4+ nonspecific Blood T cells | cell/mm3 | (160,240) | (100,600) | (241,361) | (59,272) | ||
| Effector CD4+ nonspecific Blood T cells | cell/mm3 | (200,800) | (530,110) | (445, 670) | (358,875) | ||
| Central Memory CD4+ nonspecific Blood T cells | cell/mm3 | (1,3) | (0.009,10) | (1,100) | (10,100) | ||
| Effector Memory CD4+ nonspecific Blood T cells | cell/mm3 | (1,150) | (1,22) | (1,300) | (0.3,370) | ||
| Naïve CD4+ specific LN T cells | cell count | (91957, 322492) | (8255,111806) | (144500,546200) | (5000,5720) | ||
| Precursor CD4+ specific LN T cells | cell count | 0 | 0 | (6770, 10150) | 0 | ||
| Effector CD4+ specific LN T cells | cell count | 0 | 0 | (22,34) | 0 | ||
| Central Memory CD4+ specific LN T cells | cell count | (1295,7878) | (3.4, 5046) | (2377,285871) | (3132, 59431) | ||
| Effector Memory CD4+ specific LN T cells | cell count | 0 | 0 | (828,1241) | 0 | ||
| Naïve CD4+ nonspecific LN T cells | cell count | (123430594,355639025) | (11839508, 122029962) | (177300481, 535316901) | (7865162, 53811216) | ||
| Central Memory CD4+ nonspecific LN T cells | cell count | (775507,4253381) | (1229, 1895598) | (1219316, 134489106) | (1401106, 19893946) | ||
| APC (Prime Vaccination of H56) | cell count | (150,800) | (200,500) | (350,500) | (500,1000) | ||
| APC (Boost Vaccination 1 of H56) | cell count | (50, 150) | (200,500) | (250,500) | (400,600) | ||
| APC (Boost Vaccination 2 of H56) | cell count | ***** | ***** | (200,500) | ***** | ***** | (400,600) |
The disparity between initial condition values that preceded the NHP response and those corresponding values for the human response represent the impact of prior presentation of Ag85B via BCG on the system.
*****
signifies that NHP experimental protocol did not give the NHPs a second boost of H56 vaccination.