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. 2018 Aug 17;9:1886. doi: 10.3389/fmicb.2018.01886

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Copyright © 2018 Yang, Zhong, Zhang, Li, Yu, Xiao, Jia, Ding, Ma, Wang, Yue, Liang, Sheng, Sun, Huang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The three levels of multi-copy core genes in the 36 Mtb strains. Rows represent the 36 Mtb strains and columns represent the “multi-copy core genes” (i.e., core genes with more than one copy in at least one strain). The “multi-copy core genes” were classified into one of three levels: “super-core genes (SCGs)”, “high-level core genes (HCGs)”, or “middle-level core genes (MCGs)”. SCGs were defined as those core genes containing more than one copy in more than 90% of strains; HCGs were defined as those core genes containing more than one copy in 50–90% of strains, and; MCGs were defined as those core genes containing more than one copy in at least one strain. The color intensity indicates the copy number for each gene.