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. 2018 Jul;188(7):1536–1554. doi: 10.1016/j.ajpath.2018.03.019

Figure 1.

Figure 1

MNV-4–induced disease in Stat1−/− mice. Female Stat1−/− mice were infected with MNV-4 or gavaged with lysate control and necropsied 62 days p.i. A: Gross image of an MNV-4–infected mouse with enlarged spleen and liver lesions. B: Enlarged mesenteric lymph nodes of the same mouse with higher magnification of attached mesentery shown in the inset. C: Spleen with inflammatory foci in another MNV-4–infected mouse. Inset: High magnification of pyogranulomatous foci. D: Liver with periportal inflammation and bridging pyogranuloma. Inset: Liver pyogranuloma. E: Colon and attached mesentery. Insets: Intralymphatic pyogranulomatous inflammation (left inset) and mild chronic-active mucosal inflammation (right inset). All histology panels are stained with hematoxylin and eosin. n = 10 MNV-4-infected (5 MNV-4H and 5 MNV-4C); n = 3 (lysate control). Original magnification: ×40 (B, C, and E, main images); ×400 (B, inset); ×100 (D, main image, and E, inset); ×200 (C and D, insets).