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cAMP signaling roles for hub genes in IBS-associated modules. Directionality of arrows indicates upstream/downstream of cAMP. Dotted lines indicate a negative correlation with the module eigengene. Note that CACNA1G in the guanine nucleotide exchange factor (GEF) activity module is a different isoform than in the cAMP/PKA (Fig. 3). Module memberships and P values are shown in Table 6.
