Table 10.
Expression of neuronal and glial/astrocytic markers
| IBS-C vs. HC | IBS vs. HC | IBS-D vs. HC | ||
|---|---|---|---|---|
| Gene Name, Symbol (alias, Entrez ID) | Mean | FC (p) | FC (p) | FC (p) |
| Neuronal | ||||
| Enolase2, ENO2 (neuron speific enolase, 2026) | 6.8 | 1.0 (0.62) | 1.0 (0.74) | 1.1 (0.29) |
| Ubiquitin C-terminal hydrolase L1, UCHL1 (PGP9.5, 7345) | 9.0 | 0.8 (0.2) | 1.0 (0.9) | 1.3 (0.1) |
| Microtubule associated protein 2, MAP2 (4133) | 5.0 | 1.2 (0.12) | 1.1 (0.42) | 1.2 (0.31) |
| 8.2 | 0.9 (0.35) | 1.0 (0.96) | 1.0 (0.84) | |
| Synaptophysin, SYP (6855) | 6.5 | 1.1 (0.15) | 1.1 (0.43) | 1.0 (0.93) |
| Neurofilament, heavy, NEFH (4744) | 15.2 | 1.0 (0.74) | 1.0 (0.39) | 0.9 (0.24) |
| Calbindin 2, CALB2 (calretinin, 794) | 9.2 | 0.8 (0.14) | 0.9 (0.3) | 1.0 (0.77) |
| 7.5 | 0.6 (0.04) | 0.7 (0.04) | 0.7 (0.13) | |
| Astrocyte/glial | ||||
| Proteolipid protein 1, PLP1 (5354) | 7.3 | 0.8 (0.08) | 0.9 (0.49) | 1.1 (0.54) |
| 6.3 | 0.9 (0.46) | 1.0 (0.72) | 1.0 (0.9) | |
| S100 calcium binding protein B, S100B (6285) | 6.1 | 0.8 (0.14) | 1.0 (0.8) | 0.9 (0.28) |
| Glial fibrillary acidic protein, GFAP (2670) | 7.9 | 0.9 (0.56) | 0.9 (0.4) | 0.9 (0.38) |
Mean is mean log2 normalized signal; FC, fold change.