Table 3.
Genes differentially expressed in IBS-C vs. HC concordant in Mayo
| Name (Symbol) | AveExpr | FC (FDR) |
|---|---|---|
| Upregulated | ||
| Autophagy related 7 (ATG7) | 10.99 | 1.2 (0.031) |
| Centriole, cilia and spindle associated protein (CCSAP) | 8.90 | 1.4 (0.04) |
| Centromere protein J (CENPJ)* | 7.63 | 1.4 (0.032) |
| Cofilin 2 (CFL2) | 10.05 | 1.5 (0.015) |
| Family with sequence similarity 161 member A (FAM161A) | 7.47 | 1.4 (0.022) |
| FERM, ARH/RhoGEF and pleckstrin domain protein 1 (FARP1)* | 8.97 | 1.3 (0.026) |
| Folliculin (FLCN)* | 9.81 | 1.3 (0.041) |
| IKBKB interacting protein (IKBIP) | 8.38 | 1.5 (0.035) |
| Interleukin 17 receptor D (IL17RD) | 8.26 | 1.4 (0.029) |
| IQ motif containing GTPase activating protein 2 (IQGAP2)* | 12.94 | 1.3 (0.048) |
| Kelch repeat and BTB domain containing 3 (KBTBD3) | 8.24 | 1.3 (0.025) |
| MAGE family member D4B (MAGED4/MAGED4B) | 9.07 | 1.4 (0.024) |
| Mitochondrial calcium uptake 1 (MICU1) | 8.00 | 1.3 (0.046) |
| NFU1 iron-sulfur cluster scaffold (NFU1) | 9.91 | 1.4 (0.032) |
| N-acetylneuraminate pyruvate lyase (NPL)* | 9.61 | 1.7 (0.022) |
| PostGPI attachment to proteins 1 (PGAP1) | 7.54 | 1.6 (0.031) |
| Reticulon 3 (RTN3) | 8.57 | 1.3 (0.049) |
| SRY-box 5 (SOX5) | 8.02 | 1.4 (0.03) |
| Sperm flagellar 2 (SPEF2) | 7.31 | 1.6 (0.033) |
| TIA1 cytotoxic granule associated RNA binding protein like 1 (TIAL1)* | 9.36 | 1.3 (0.027) |
| Transmembrane protein 44 (TMEM44) | 7.44 | 1.5 (0.003) |
| WD repeat domain 19 (WDR19) | 8.66 | 1.3 (0.047) |
| Zinc finger protein, FOG family member 2 (ZFPM2)* | 8.43 | 1.7 (0.01) |
| Zinc finger protein 789 (ZNF789)* | 7.44 | 1.3 (0.032) |
| Downregulated | ||
| Acyl-CoA thioesterase 7 (ACOT7)* | 8.58 | 0.6 (0.019) |
| Angiotensin II receptor type 2 (AGTR2) | 7.35 | 0.6 (0.019) |
| Amidohydrolase domain containing 2 (AMDHD2) | 9.54 | 0.8 (0.028) |
| Chromosome 20 open reading frame 141 (c20orf141) | 11.70 | 0.8 (0.029) |
| Coiled-coil domain containing 27 (CCDC27) | 7.81 | 0.8 (0.046) |
| Corticotropin releasing hormone receptor 1 (CRHR1) | 7.53 | 0.7 (0.018) |
| DExH-box helicase 30 (DHX30) | 8.16 | 0.8 (0.012) |
| Epsin 1 (EPN1)* | 8.23 | 0.7 (0.041) |
| Family with sequence similarity 228 member A (FAM228A) | 7.90 | 0.8 (0.038) |
| F-box and leucine rich repeat protein 18 (FBXL18)* | 7.55 | 0.7 (0.013) |
| F-box protein 40 (FBXO40) | 7.81 | 0.4 (0.032) |
| Fibronectin type III domain containing 11 (FNDC11/C20orf195) | 9.56 | 0.8 (0.03) |
| GDNF family receptor alpha 4 (GFRA4) | 11.93 | 0.7 (0.045) |
| Interleukin 17 receptor E (IL17RE)* | 10.46 | 0.7 (0.025) |
| Inositol-3-phosphate synthase 1 (ISYNA1)* | 8.84 | 0.8 (0.01) |
| Lipoxygenase homology domains 1 (LOXHD1) | 9.48 | 0.7 (0.021) |
| Leucine rich repeat containing 27 (LRRC27) | 8.87 | 0.8 (0.029) |
| Mitogen-activated protein kinase kinase 7 (MAP2K7) | 11.66 | 0.7 (0.036) |
| Myosin light chain kinase 2 (MYLK2) | 14.59 | 0.5 (0.008) |
| Nectin cell adhesion molecule 1 (NECTIN1) | 8.27 | 0.6 (0.01) |
| Nectin cell adhesion molecule 4 (NECTIN4) | 10.16 | 0.7 (0.029) |
| Neuropeptides B and W receptor 1 (NPBWR1)* | 7.73 | 0.6 (0.017) |
| NUT family member 2D (NUTM2D) | 9.59 | 0.8 (0.046) |
| Pregnancy specific beta-1-glycoprotein 6 (PSG6) | 12.64 | 0.6 (0.01) |
| Purine rich element binding protein A (PURA)* | 12.90 | 0.7 (0.026) |
| RNA exonuclease 1 homolog (REXO1) | 9.43 | 0.7 (0.039) |
| SCO-spondin (SSPO) | 9.15 | 0.8 (0.029) |
| Synaptogyrin 2 (SYNGR2) | 11.12 | 0.8 (0.034) |
| TAP binding protein (TAPBP)* | 9.20 | 0.7 (0.013) |
| Chromosome 14 open reading frame 80 (TEDC1) | 13.37 | 0.5 (0.014) |
| Chromosome 16 open reading frame 59 (TEDC2)* | 10.55 | 0.5 (0.008) |
| T-SNARE domain containing 1 (TSNARE1) | 8.89 | 0.7 (0.008) |
| Ubiquitin associated protein 1 like (UBAP1L) | 8.95 | 0.8 (0.041) |
AveExpr, average expression (log2 transformed); FC, fold change, FDR, Benjamini-Hochberg adjusted P value.
*
Also differentially expressed in this direction in Nottingham.