Figure 1.
Schematic representation of the subventricular zone (SVZ) neurogenic niche. The niche is located underneath the ependymal cells (in orange) lining the lateral ventricle (LV). It is constituted by type B neural stem cells (in blue, B) which can activate and generate type C neural progenitor cells (NPCs; in green, C) that proliferate rapidly and generate type A neuroblasts (in red, A). Type B cells extend a short apical process to contact the cerebrospinal fluid (CSF) and a long basal process that terminate on blood vessels (BVs). Astrocytes (in pale blue) contact BVs, ependymal cells and type C cells and surround migrating neuroblasts towards the olfactory bulb. Microglial cells (in gray) contact type A, type B and type C cells and also BVs.