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. 2018 Aug 20;9:1942. doi: 10.3389/fmicb.2018.01942

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Copyright © 2018 Golkar, Zieliński and Berghuis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Macrolide binding to the 23S rRNA. (A) The binding of erythromycin to the ribosome is shown. Highlighted also is A2058 and the hydrogen bond it makes with the 2′ hydroxyl of the desosamine moiety. (B) Additional macrolides are shown illustrating the similarity in their binding modes. Depicted are erythromycin (purple; pdb code: 4V7U), azithromycin (green; pdb code: 1M1K), carbomycin A (cyan; pdb code: 1K8A) and the ketolide telithromycin (yellow; pdb code: 4V7S). The figure was prepared using PyMOL (Schrödinger, 2017).